Deep Impact progeny Auguste Rodin, guided by Ryan Moore, dashed to the front after the Breeders' Cup Turf's final turn and secured a narrow win.
Sparked by a "perfect start," according to trainer Yoshito Yahagi, jockey Yutaka Yoshida and Panthalassa win the world's richest horse race.
The 2021 Tokyo Yushun winner competed in big races in the United Arab Emirates and England in March and June, respectively, before returning home.
“As the level of Japanese racehorses has increased over the years, I’ve been really proud to showcase it on the global stage,” trainer Yoshito Yahagi said.
The Japanese Derby winner will be racing against Contrail, Wagnerian and Makahiki, making the race a unique event featuring four Derby winners from four different generations.